Crystal structure of Schistosoma mansoni HGPRT isoform 1
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چکیده
منابع مشابه
Crystal Structure of Schistosoma mansoni Arginase, a Potential Drug Target for the Treatment of Schistosomiasis
The X-ray crystal structure of arginase from Schistosoma mansoni (SmARG) and the structures of its complexes with several amino acid inhibitors have been determined at atomic resolution. SmARG is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of l-arginine to form l-ornithine and urea, and this enzyme is upregulated in all forms of the parasite that interact with the human ho...
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a Departamento de Bioquı́mica Médica, Uni6ersidade Federal do Rio de Janeiro, Cidade Uni6ersitária, 21941-590, Rio de Janeiro, RJ, Brazil b Di6isão de Quı́mica, Setor de Quı́mica Orgânica, CENPES, Petrobrás, Cidade Uni6ersitária, 21949-900, Rio de Janeiro, RJ, Brazil c Centro de Biociências e Biotecnologia, Uni6ersidade Estadual do Norte Fluminense, Campos dos Goytacazes, RJ, 28015-620, Brazil d I...
متن کاملSchistosoma mansoni associated glomerulopathy.
(1)Institute of Tropical Medicine, São Paulo, SP, Brasil. (2)Division of Nephrology, “Hospital das Clinicas”, University of S. Paulo, Medical School, S. Paulo, SP, Brasil. (3)São Paulo Federal University Medical School, Dept. of Microbiology, Immunology, and Parasitology, S. Paulo, SP, Brazil. Correspondence to: Dr. Thales De Brito, Av. Dr. Enéas de Carvalho Aguiar 470, 05403–000 S. Paulo, SP, ...
متن کاملSchistosoma Mansoni Shares
The production of mAbs of various isotypes to Schistosoma mansoni has greatly contributed to the appreciation of the function of antibodies in the immunity against schistosomiasis, and has allowed the characterization of several potential protective antigens . Using this approach, we clearly established in previous studies (1, 2) the close relationship existing between a 38,000 Mr S. mansoni sc...
متن کاملCarbohydrate Metabolism of Schistosoma Mansoni
1. Schistosoma mansoni utilizes in 1 hour an amount of glucose equivalent to one-sixth to one-fifth of its dry weight. Over 80 per cent of the metabolized glucose is converted to lactic acid by this organism. 2. The rates of glucose utilization and of lactic acid production by S. mansoni are the same under aerobic and under anaerobic conditions. 3. A high rate of lactic acid production and the ...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations and Advances
سال: 2014
ISSN: 2053-2733
DOI: 10.1107/s2053273314091669